Central Serotonin and Impulsive Aggression

Coccaro, Emil F.

doi:10.1192/s0007125000291769

Cited by 422 publications

(205 citation statements)

References 89 publications

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“…On the basis of pre-clinical and clinical data, Soubrié (1986) proposed that a reduction in serotonergic activity facilitates active responses at the expense of behavioral inhibition and can result in impulsive behavior in circumstances where an active response is inappropriate and results in either an aversive event or omission of reinforcement. This is in line with clinical evidence that low levels of 5-HIAA are associated with impulsive behavior in the context of certain psychiatric disorders (eg Coccaro, 1989;Linnoila et al, 1993) and with evidence that neuroendocrine responses to fenfluramine are significantly elevated in substance abusers with higher levels of impulsivity (Fishbein et al, 1989).…”

Section: Introductionsupporting

confidence: 87%

Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve Controls

Morgan

Impallomeni

Pirona

et al. 2005

Neuropsychopharmacol

111

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Section: Introductionsupporting

confidence: 87%

Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve Controls

Morgan

Impallomeni

Pirona

et al. 2005

Neuropsychopharmacol

111

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“…Important distinctions among aggressive subtypes include: level of planning, appreciation for consequences, and affective intensity associated with the aggressive acts. Based on these distinctions, researchers investigating aggressive subtypes in human adults and young children have commonly concluded that there is a dichotomy of aggressive subtypes that have variously been described as: [a] impulsive, reactive, affective, or non-planned;and [b] premeditated, proactive, instrumental, predatory, or controlled (e.g., Heilbrun et al, 1978;Coccaro, 1989;Barratt et al, 1997a;Vitaro et al, 2002;McEllistrem, 2004). For the purpose of this investigation, the terms impulsive aggression and premeditated aggression are used to facilitate comparison to similar adult literature (Stanford et al, 2003a;Kockler et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, impulsive aggressive adults have diminished language ability (Barratt et al, 1997b) and lower cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations (Linnoila et al, 1983), relative to premeditated aggressors. Compared to non-aggressive adults, impulsive aggressors have reduced executive functioning (Villemarette-Pittman et al, 2002) and decreased cortical activation (Mathias and Stanford, 1999;Houston and Stanford, 2001), as well as central serotonergic dysregulation (Coccaro, 1989;Coccaro, et al, 1991;. Further, impulsive aggression is associated with self-reported impulsivity, neuroticism, physical aggression, and anger (Stanford et al, 2003a).…”

Section: Introductionmentioning

confidence: 99%

Characterizing aggressive behavior with the Impulsive/Premeditated Aggression Scale among adolescents with conduct disorder

Mathias

Stanford

Marsh

et al. 2007

Psychiatry Research

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This study extends the use of the Impulsive/Premeditated Aggression Scale for subtyping aggressive behavior among adolescents with Conduct Disorder. Of the Conduct Disorder symptoms, aggression has the strongest prognostic and treatment implications. While aggression is a complex construct, convergent evidence supports a dichotomy of impulsive and premeditated aggressive subtypes that are qualitatively different from one another in terms of phenomenology and neurobiology. Previous attempts at measuring subtypes of aggression in children and adults are not clearly generalizable to adolescents. Sixty-six adolescents completed a questionnaire for characterizing aggression (Impulsive/Premeditated Aggression Scale), along with standard measures of personality and general functioning. Principal components analysis demonstrated two stable factors of aggression with good internal consistency and construct validity. Compared to the premeditated aggression factor, the impulsive aggression factor was associated with a broader range of personality, thought, emotional, and social problems. As in the adult and child literature, characterization of aggressive behavior into two subtypes appears to be relevant to understanding individual differences among adolescents with Conduct Disorder.

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“…The study of serotonin (5-HT) and its major metabolites is of continuing interest because impaired 5-HT mediated neural functioning has been associated with a variety of psychopathological problems such as inappropriate aggression (Brown et al 1979;Higley et al 1992aHigley et al , 1996bLinnoila et al 1983;Mehlman et al 1995;Virkkunen et al 1994a), excessive alcohol use Coccaro 1989;Higley et al 1996a,b;Virkkunen et al 1994), impaired social interactions (Higley et al 1994Raleigh et al 1980;Raleigh and McGuire 1991), as well as sleep difficulties (Zajicek et al 1997), and reduced social competence (Higley et al 1996c;Kruesi et al 1990) in both humans and nonhuman primates.…”

mentioning

confidence: 99%