“…One possible route for the movement of SARS-CoV-2 into digestive system may be "trachea-esophagus-ileum-colon" as single-cell transcriptom analysis showed ACE2, the entry receptor for SARS-CoV-2, highly expressed in lung AT2 cells, esophagus upper and stratified epithelial cells and enterocytes from ileum and colon 6 . The evidence for this route is that all of the specimens including pharyngeal swab, esophageal biopsy, gastric mucosa, rectal mucosa, duodenal mucosa and stool tested positive to SARS-CoV-2 in two cases 7 . Another route may be bloodstream infection since SARS-CoV-2 was directly detected in bleeding site in one case 7 .…”