Background: Internet interventions have been proposed to improve the accessibility and utilization of evidence-based psychological treatments. However, little is known about attitudes toward such treatments, which can be an important barrier to their utilization. Objective: This study aimed to (1) determine attitudes toward guided internet interventions, to (2) assess its acceptability compared to other internet-based formats, and to (3) explore predictors of acceptance. Methods: A web-based survey (N=646) assessed attitudes toward guided internet therapies (i.e. "perceived usefulness/helpfulness", "relative advantage compared to face-to face therapy"), preferences for delivery modes ("e-preference": guided Internet interventions, unguided internet interventions, video conferencing psychotherapy (VCP)) as well as potential predictors of attitudes and preferences, including socio-demographics, help seeking-related variables, attachment style, perceived stress. Results: Although most participants perceived internet interventions as useful or helpful (65.9%, 426/646), the minority indicated their relative advantage compared to face-to-face therapy (8.7%, 56/646). Most participants preferred guided internet interventions (39.0%, 252/646) over VCP (22.8%, 147/646), unguided internet interventions (19.2%, 124/646) and not using internet interventions (18.8%, 121/646; missing: 0.2%). Attachment avoidance and stress were related to epreference (all P<.05). Moreover, preference for therapist-guided internet interventions was higher for individuals aware of internet-based treatment (χ