“…Findings of connectivity changes inside and to the DMN in relation to APOE‐ε4 carriership have not been consistent, mostly due to the different age groups being studied (Filippini et al., 2011; Heise, Filippini, Ebmeier, & Mackay, 2011; Mevel, Chételat, Eustache, & Desgranges, 2011). Overall, the most frequently reported changes are weakened DMN connectivity in middle‐aged and older subjects (Goveas et al., 2013; Machulda et al., 2011; Reiman et al., 1996; Sheline et al., 2010; Wang et al., 2012) and, less frequently, increased DMN connectivity in young adults (Filippini et al., 2009; Fleisher et al., 2009).…”