Disseminated skeletal muscle and cardiac metastasis from squamous cell carcinoma of the lung detected with FDG and FLT PET/CT

Jain, Tarun; Rayamajhi, Sampanna Jung; Basher, Rajender Kumar; Gupta, Dheeraj; Maturu, Venkata Nagarjuna; Mittal, Bhagwant Rai

doi:10.4103/1450-1147.167607

Cited by 2 publications

(4 citation statements)

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“…[ 5 ] Several hypotheses do exist regarding muscle resistance like acidic pH due to lactic acid, muscle contractibility, tissue pressure, variable blood flow, oxygen free-radical production, cellular and humoral immunity, and hypersensitivity reactions. [ 5 6 7 ] The most common primaries with SMM are from gastrointestinal and genitourinary tract malignancies,[ 3 ] with an incidence of 0.8%–1% SMM. [ 4 ] Wittich in 1854 reported the first incidence of SMM, while Willis first reported SMM from lung.…”

Section: Discussionmentioning

confidence: 99%

“…SMM occurs more commonly in males compared to females with smoking as the principal predisposing factor. [ 5 8 10 ] For SMM, pain is the most common symptom followed by palpable mass[ 2 3 4 5 6 7 8 9 10 ] whether SMM gets detected before or synchronously within 6 months or metachronously after 6 months of diagnosis of primary. [ 5 ] A painful mass has often been associated with SMM in contrast to STS,[ 8 ] while a silent SMM like our case has been scarcely reported.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] 18FDG-PET/CT identifies regions of active proliferation within the primary tumor and SMM. FDG is a surrogate marker of tumor cell metabolism and proliferation and increases the diagnostic specificity[ 6 ] as compared to CT and MRI, thus making it the imaging modality of choice for metastatic workup. The possible differentials for focal and diffuse muscle uptake of FDG along with their imaging characteristics are given below [ Table 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…18FDG-PET/CT scan is the imaging modality of choice for detecting SMM. [ 6 ] Histopathology (HPR) remains the gold standard of differentiation from soft-tissue sarcomas (STS)[ 2 7 ] and initiation of appropriate therapeutic modality, though no definitive measure does exist due to its rarity. [ 5 8 ]…”

Section: Introductionmentioning

confidence: 99%

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Upfront skeletal muscle metastases from non-small cell lung carcinoma: Report of an extremely rare occurrence detected by 18F-fluorodeoxyglucose positron emission computed tomography scan

et al. 2018

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Adenocarcinoma lung with upfront metastases to skeletal muscle is rarely encountered in clinical practice since skeletal muscles are highly resistant to dissemination from solid organs. Moreover, these muscle metastatic lesions generally present with pain and palpable mass to get detected clinically. However, silent skeletal muscle metastases without any symptoms or signs getting detected by functional imaging with whole body 18F-fluorodeoxyglucose positron emission/computed tomography (18FDG-PET/CT) scan have been scarcely described in literature, while we present such an interesting case in a 45-year-old female. She was diagnosed as a case of biopsy-proven metastatic adenocarcinoma lung after evaluation by 18FDG-PET/CT. Despite treatment with palliative chemoradiotherapy, her disease progressed, and she finally succumbed to her illness. This case is discussed to highlight an unusual scenario we encountered, the clinical course of the disease with its management and overall poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Upfront skeletal muscle metastases from non-small cell lung carcinoma: Report of an extremely rare occurrence detected by 18F-fluorodeoxyglucose positron emission computed tomography scan

et al. 2018

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Right ventricle metastasis from carcinoma rectum: Findings on¹⁸F-fluorodeoxyglucose positron emission tomography–computed tomography

Tripathy¹,

Parida

Naswa³

et al. 2020

Indian J Nucl Med

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Disseminated skeletal muscle and cardiac metastasis from squamous cell carcinoma of the lung detected with FDG and FLT PET/CT

Cited by 2 publications

References 8 publications

Upfront skeletal muscle metastases from non-small cell lung carcinoma: Report of an extremely rare occurrence detected by 18F-fluorodeoxyglucose positron emission computed tomography scan

Upfront skeletal muscle metastases from non-small cell lung carcinoma: Report of an extremely rare occurrence detected by 18F-fluorodeoxyglucose positron emission computed tomography scan

Right ventricle metastasis from carcinoma rectum: Findings on¹⁸F-fluorodeoxyglucose positron emission tomography–computed tomography

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Disseminated skeletal muscle and cardiac metastasis from squamous cell carcinoma of the lung detected with FDG and FLT PET/CT

Cited by 2 publications

References 8 publications

Upfront skeletal muscle metastases from non-small cell lung carcinoma: Report of an extremely rare occurrence detected by 18F-fluorodeoxyglucose positron emission computed tomography scan

Upfront skeletal muscle metastases from non-small cell lung carcinoma: Report of an extremely rare occurrence detected by 18F-fluorodeoxyglucose positron emission computed tomography scan

Right ventricle metastasis from carcinoma rectum: Findings on18F-fluorodeoxyglucose positron emission tomography–computed tomography

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Right ventricle metastasis from carcinoma rectum: Findings on¹⁸F-fluorodeoxyglucose positron emission tomography–computed tomography