2009
DOI: 10.1007/s00213-009-1635-z
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Effects of MDMA on sociability and neural response to social threat and social reward

Abstract: RATIONALE ±3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) reportedly produces unique subjective effects, including increased sociability, feelings of closeness with others, and reduced interpersonal defensiveness. Despite their apparent importance in recreational and potential psychotherapeutic use of MDMA, the defining characteristics and neurobiological mechanisms of these interpersonal effects are poorly understood. MATERIALS AND METHODS We investigated acute effects of MDMA on self-reported sociabil… Show more

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Cited by 158 publications
(181 citation statements)
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“…Intranasal oxytocin produced small increases in selfreported sociability but, in contrast to MDMA, oxytocin (40 IU) enhanced recognition of negative emotional faces, suggesting that MDMA-and oxytocin-related effects are not synonymous. Overall, these data are consistent with previous reports of the prosocial effects of MDMA (Bedi et al, 2009(Bedi et al, , 2010Kirkpatrick et al, 2012;Tancer and Johanson, 2003) and extend these earlier findings by demonstrating modest correlations between the effects of MDMA and oxytocin in the same individuals. MDMA dose-dependently increased subjective ratings of sociability and 'positive' mood.…”
Section: Discussionsupporting
confidence: 91%
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“…Intranasal oxytocin produced small increases in selfreported sociability but, in contrast to MDMA, oxytocin (40 IU) enhanced recognition of negative emotional faces, suggesting that MDMA-and oxytocin-related effects are not synonymous. Overall, these data are consistent with previous reports of the prosocial effects of MDMA (Bedi et al, 2009(Bedi et al, , 2010Kirkpatrick et al, 2012;Tancer and Johanson, 2003) and extend these earlier findings by demonstrating modest correlations between the effects of MDMA and oxytocin in the same individuals. MDMA dose-dependently increased subjective ratings of sociability and 'positive' mood.…”
Section: Discussionsupporting
confidence: 91%
“…Interestingly, the drug also increased several 'negative' subjective ratings such as drug disliking, and feelings of anxiety and loneliness. Overall, these subjective data are consistent with other studies indicating that MDMA produces both 'positive' and 'negative' mood states under controlled laboratory conditions (Bedi et al, 2009(Bedi et al, , 2010Kirkpatrick et al, 2012;Tancer and Johanson, 2003). This mixed profile of both positive and negative subjective effects is consistent with the purportedly low abuse potential of MDMA relative to other amphetamines (Kirkpatrick et al, 2012).…”
Section: Discussionsupporting
confidence: 90%
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“…One study (N = 10) was an fMRI investigation of MDMA (0.75mg/kg; 1.5 mg/kg) effects on social processing [3]. The second (N = 25) examined the effects of MDMA (0.75mg/kg; 1.5 mg/kg) and methamphetamine (20mg) on social cognition.…”
Section: Methodsmentioning
confidence: 99%