Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: a randomized trial

Gorka, Stephanie M.; Young, Christina B.; Klumpp, Heide; Kennedy, Amy E.; Francis, Jennifer; Ajilore, Olusola; Langenecker, Scott A.; Shankman, Stewart A.; Craske, Michelle G.; Stein, Murray B.; Phan, K. Luan

doi:10.1038/s41386-019-0407-7

Cited by 75 publications

(53 citation statements)

References 44 publications

(46 reference statements)

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“…See Table 1 for clinical and demographic characteristics and comorbid diagnoses. A portion of participants were previously reported ( Gorka et al, 2019 , Klumpp et al, 2013 , MacNamara et al, 2017 , Phan et al, 2013 ), however, the research topics differed from the current study.…”

Section: Methodsmentioning

confidence: 70%

“…All participants performed an Emotional Face Matching Task shown to engage regions involved in emotion processing ( Gorka et al, 2019 , Klumpp et al, 2013 , MacNamara et al, 2017 , Phan et al, 2013 ). Participants viewed a trio of faces (one target at the top, two probes on the bottom) consisting of photographs from a validated set of face stimuli ( Gur et al, 2002 ) presented in a block design.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Individual differences in striatal and amygdala response to emotional faces are related to symptom severity in social anxiety disorder

Crane

Chang

Kinney

et al. 2021

NeuroImage: Clinical

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Section: Methodsmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Individual differences in striatal and amygdala response to emotional faces are related to symptom severity in social anxiety disorder

Crane

Chang

Kinney

et al. 2021

NeuroImage: Clinical

Self Cite

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“…19 (Fitzgerald et al, 2017b) Non-significant results 20 (Schmitt et al, 2016) Non-significant results 21 (Light et al, 2011) Non-significant results 22 (Yip et al, 2018) Non-significant results 23 (Hilland et al, 2018) Lacking healthy controls 24 Lacking healthy controls Table S1. List of excluded studies with reasons 25 (Contreras-Rodríguez et al, 2020) Lacking healthy controls 26 (Fitzgerald et al, 2019) Lacking healthy controls 27 (Schmitgen et al, 2019) Lacking healthy controls 28 (Gorka et al, 2019) Lacking healthy controls 29 (Klumpp et al, 2017b) Lacking healthy controls 30 (Fonzo et al, 2017b) Lacking healthy controls 31 (Fonzo et al, 2017a) Lacking healthy controls 32 (Klumpp et al, 2017a) Lacking healthy controls 33 (Reinecke et al, 2018) Lacking healthy controls 34 (Klumpp et al, 2017c) Lacking healthy controls 35 (Goldin et al, 2014) Lacking healthy controls 36 (Reinecke et al, 2014) Lacking healthy controls 37 (Brühl et al, 2013) Lacking healthy controls 38 (Goldin et al, 2013a) Lacking healthy controls 39 (Heller et al, 2013) Lacking healthy controls 40 (Goldin et al, 2013b) Lacking healthy controls 41 (Hermann et al, 2009) Lacking healthy controls 42 (Kanske et al, 2015) Non-whole-brain analysis 43 (Rabinak et al, 2014) Non-whole-brain analysis 44 (Kanske et al, 2012) Non-whole-brain analysis 45 (Lang et al, 2012) Non-whole-brain analysis 46 (Erk et al, 2010) Non-whole-brain analysis 47 (Douw et al, 2020) Non-whole-brain analysis 48 (Klumpp et al, 2019) Non-whole-brain analysis 49 (Jacob et al, 2019) Non-whole-brain analysis 50 (Young et al, 2019) Non-whole-brain analysis 51 (Zhang et al, 2018) Non-whole-brain analysis 52 …”

Section: Resultsmentioning

confidence: 99%

In search of convergent regional brain abnormality in cognitive emotion regulation: a transdiagnostic neuroimaging meta-analysis

khodadadifar¹,

Soltaninejad²,

Ebneabbasi³

et al. 2020

Preprint

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Cognitive emotion regulation (i.e., reappraisal) impairment is a key feature in a wide variety of mental disorders, suggesting common nature of disruption across psychiatric diagnoses. However, the extent of potential shared neurobiological disturbances related to reappraisalimpairment is incompletely understood. This study, therefore, aimed to identify neurobiological substrates of disturbed reappraisal using a transdiagnostic approach by performing a quantitative coordinate-based meta-analysis (CBMA) on reappraisal tasks across various mental disorders. Following the best-practice guidelines for neuroimaging meta-analysis, we systematicallysearched PubMed, ScienceDirect and Web of Science databases for whole-brain neuroimaging studies published through February 2020 that compared brain activation in patients with mental disorders and matched healthy controls during a reappraisal task. Out of 1608 publications, we retrieved 32 publications with 1240 unique individuals, providing sufficient power for conducting CBMA using activation likelihood estimation (ALE) method. The reported peak coordinates for the patient/control difference in selected articles were extracted and several ALE analyses were performed to identify spatial convergence. Surprisingly, neither the pooled ALE analysis noradditional analyses restricting to in-/decreased contrasts and more homogeneous grouping of coordinates (i.e., regulation direction, stimulus valence and disorder category) provided significant convergent findings. This CBMA indicates a lack of convergent regional abnormality related to reappraisal across various mental disorders. This might be due to the complex nature of reappraisal, heterogeneous clinical populations or methodological flexibility including preprocessing and analytical methods.

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“…Fluoxetine, a selective serotonin reuptake inhibitor, is the sole FDA-approved medication for bulimia nervosa (another eating disorder characterized by recurrent binge eating) following a series of RCTs that found efficacy relative to placebo. 206e208 In addition, selective serotonin reuptake inhibitors reduce emotional reactivity 209 and symptoms of obsessivecompulsive disorder. 210 However, serotonergic agents have consistently had weak to nonsignificant effects in RCTs with BED for both binge eating and weight outcomes.…”

Section: Serotonergic Agents: Effects On Emotion Reactivity?mentioning

confidence: 99%

The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics

Boswell

Potenza

Grilo

2021

Clinical Therapeutics

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Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: a randomized trial

Cited by 75 publications

References 44 publications

Individual differences in striatal and amygdala response to emotional faces are related to symptom severity in social anxiety disorder

Individual differences in striatal and amygdala response to emotional faces are related to symptom severity in social anxiety disorder

In search of convergent regional brain abnormality in cognitive emotion regulation: a transdiagnostic neuroimaging meta-analysis

The Neurobiology of Binge-eating Disorder Compared with Obesity: Implications for Differential Therapeutics

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