Exercise manages fatigue during breast cancer treatment: A randomized controlled trial

Mock, Victoria; Frangakis, Constantine; Davidson, Nancy E.; Ropka, Mary E.; Pickett, Mary; Poniatowski, Barbara; Stewart, Kerry J.; Cameron, Lane; Zawacki, Kristin L.; Podewils, Laura Jean; Cohen, Gary I.; McCorkle, Ruth

doi:10.1002/pon.863

Cited by 325 publications

(294 citation statements)

References 61 publications

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“…Moreover, the role of attention, motivation, and social interaction in connection with the positive effects of exercise on CRF needs to be further evaluated. 6 Data from this study concurs with the literature, 16 showing that exercise programs, with aerobic and resistance exercises, are an effective strategy for the treatment of CRF, and will improve physical performance during and following cancer treatment. 17 …”

Section: Discussionsupporting

confidence: 84%

Impact of two different exercise programs on persistent cancer-related fatigue and physical fitness

et al. 2012

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A fadiga relacionada ao câncer é um dos sintomas mais comuns entre pacientes com câncer, relatada em 70% a 100% desses pacientes resultando em uma redução significativa da qualidade de vida, funcionalidade e independência. O exercício físico tem sido identificado como um elemento central de reabilitação de muitas doenças crônicas como câncer, e cada vez mais evidências apoiam a tese de que a atividade física é uma intervenção útil, que pode ser utilizada em conjunto com terapias convencionais durante o tratamento da fadiga relacionada ao câncer. Objetivo: O objetivo deste estudo é avaliar o impacto de dois programas de exercício físico sobre os níveis de fadiga e desempenho físico de pacientes com câncer. Método: Relato de uma série consecutiva de 44 doentes adultos com doença neoplásica (sólido ou hematológicas), e diagnós-tico médico de fadiga, submetidos a dois diferentes programas de exercício físico. Todos os doentes foram avaliados quanto a desempenho físico com o uso do teste de caminhada de 6 minutos e avaliados quanto aos níveis de fadiga com o teste de Piper, antes e depois de 4 meses de atividade física supervisionada (exercícios aeróbicos isolados e treino de resistência combinado ao exercícios aeróbicos). Resultados: Após 16 semanas, os doentes que participaram do programa de exercícios aeróbicos ou que participaram do protocolo de exercício aeróbico combinado com anaeróbio, relataram níveis significativamente mais elevados do desempenho físico (6 minutos teste de caminhada, p = 0,0009 e p = 0,001, respectivamente) e níveis de fadiga significativamente menor (PFS-R, p = 0,003 e p = 0,002, respectivamente) do que no início do programa de exercícios. Conclusão: Estes resultados demonstram que tanto um protocolo de exercício aeróbico quanto de exercício aeróbico combinado com exercício anaeróbio apresentam melhora significativa do desempenho físico e dos níveis de fadiga de doentes oncológicos. Os dados deste estudo corroboram a literatura mostrando que a atividade física é uma estratégia eficaz para o tratamento da fadiga. Os resultados deste estudo confirmam que o exercício físico pode ser útil na reabilitação de sobreviventes de câncer, especialmente para pacientes com fadiga oncológica.Palavras-chave: aptidão física, exercício, fadiga, neoplasias, reabilitação ABSTRACTCancer-related fatigue is a common symptom in patients with cancer, which is experienced by 70% to 100% of these patients and brings some impairment of physical and mental performance, hinders their working or carrying out regular daily activities, and hence results in a substantial reduction of the quality of life. Physical exercise has consistently been identified as a central element of rehabilitation for many chronic diseases like cancer, and increasing evidence supports the contention that physical activity is a valuable intervention that can be utilized in conjunction with conventional therapies during CRF treatment. Objective: The aim of this study was to assess the impact of a program of physical exercise on fatigue levels and...

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Section: Discussionsupporting

confidence: 84%

Impact of two different exercise programs on persistent cancer-related fatigue and physical fitness

et al. 2012

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“…Twenty-four publications were categorized as psychological intervention studies (Badger et al, 2005;Barsevick et al, 2003;Boesen et al, 2005;Bordeleau et al, 2003;de Wit et al, 1997;Decker, Cline-Elsen, & Gallagher, 1992;Edelman, Bell, & Kidman, 1999;Fawzy et al, 1990;Forester, Kornfeld, & Fleiss, 1985;Gaston-Johansson et al, 2000;Goodwin et al, 2001;Hack et al, 2003;Jacobsen et al, 2002;Oyama, Kaneda, Katsumata, Akechi, & Ohsuga, 2000;Rawl et al, 2002;Sandgren & McCaul, 2003;Sandgren, McCaul, King, O'Donnell, & Foreman, 2000;Speca, Carlson, Goodey, & Angen, 2000;Spiegel, Bloom, & Yalom, 1981;Telch & Telch, 1986;Vos, Garssen, Visser, Duivenvoorden, & de Haes, 2004;Wenzel, Robinson, & Blake, 1995;Williams & Schreier, 2004;Wydra, 2001) and 17 were categorized as activity-based intervention studies (Burnham & Wilcox, 2002;Campbell, Mutrie, White, McGuire, & Kearney, 2005;Coleman et al, 2003;Courneya, Friedenreich, Sela et al, 2003;Courneya, Mackey et al, 2003;Drouin et al, 2005;Headley, Ownby, & John, 2004;McKenzie & Kalda, 2003;Mock et al, 1994Mock et al, , 1997Mock et al, 2005;Pinto, Clark, Maruyama, & Feder, 2003;…”

Section: Search Results and Organization Of Selected Studiesmentioning

confidence: 99%

Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue.

Jacobsen¹,

Donovan²,

et al. 2007

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Context-Fatigue is among the most common and distressing symptoms experienced by cancer patients.Objective-This systematic review and meta-analysis evaluates the efficacy of psychological and activity-based interventions against cancer-related fatigue in cancer patients. Data Sources-MEDLINE, PsycINFO, and CINAHL.Study Selection-Randomized controlled trials of psychological and activity-based interventions involving adult cancer patients in which fatigue was an outcome were reviewed.Extraction-Forty-one trials were reviewed and 30 were included in a meta-analysis.Data Synthesis-Fifty percent of psychological trials and 44% of activity-based trials rated fair or better in quality yielded significant findings favoring the intervention condition. Meta-analysis yielded an overall effect size of 0.09 (95% CI = .02 -.16) favoring nonpharmacological conditions. Further analysis indicated that effect sizes were significant for psychological interventions (d w = . 10, 95% CI = .02-.18) but not activity-based interventions (d w = .05, 95% CI = −.08 -.19).Conclusions-Findings provide limited support for use of nonpharmacological interventions to manage cancer-related fatigue. The lack of research with heightened fatigue as an eligibility criterion is a notable weakness of the existing evidence base. Keywordsfatigue; cancer; psychological interventions; activity-based interventions; randomized controlled trials Cancer-related fatigue has been defined as "a persistent subjective sense of tiredness related to cancer or cancer treatment that interferes with usual functioning" (Mock et al., 2000). Studies suggest it is among the most common symptoms experienced by cancer patients with advanced disease and those being treated with radiotherapy and chemotherapy (Ahlberg, Ekman, GastonJohansson, & Mock, 2003). Furthermore, fatigue does not appear to be limited to the active treatment period. Many individuals with no clinical evidence of disease continue to experience fatigue for months or even years following treatment completion (Servaes, Verhagen, & Bleijenberg, 2002). The clinical significance of fatigue has been examined primarily in terms of its impact on quality of life. Among patients treated with chemotherapy or radiotherapy, more than one third perceived that fatigue interfered with their ability to work, relationships with others, and physical and emotional well-being (Vogelzang et al., 1997). NIH Public AccessMechanisms involved in the development and persistence of cancer-related fatigue are only partially understood. Available evidence suggests that fatigue can occur as a consequence of metabolic changes associated with the underlying disease as well those induced by cancer treatments (Stasi, Abriani, Beccaglia, Terzoli, & Amadori, 2003). In addition, fatigue can occur as a concomitant of other common symptoms experienced by cancer patients (e.g., nausea, and pain; Stasi et al., 2003). A growing body of research also suggests that cognitive and behavioral factors may contribute to exacerbation and persistence...

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“…Similarly, Jones and Courneya (2002) found that 84% of mixed cancer survivors reported an interest in receiving exercise counselling. Contamination issues arising from randomised controlled trials have shown that cancer survivors are often keen to be active even when they are not asked to and manage to find their own motivation to be physically active outside of an intervention setting (Mock et al, 2005;Thorsen et al, 2005). Despite the barriers to physical activity that cancer survivors face, the majority of this population appear to be interested in engaging in a physical activity programme of some sort.…”

Section: Addressing Psychological Barriers To Physical Activitymentioning

confidence: 99%

“…Furthermore, maintaining some degree of physical activity attenuates the loss of, and can even improve, functional capacity PAGAC, 2008;Segal et al, 2003). Intervention studies with breast cancer survivors have demonstrated that physical activity can significantly decrease fatigue, both during treatment Mock et al, 2005;Pinto et al, 2000) and after treatment (Burnham & Wilcox, 2003;Granger et al, 2011;Shelton et al, 2009;Wilson et al, 2005). There have been fewer studies conducted with nonbreast cancer survivors, although there is some evidence that physical activity also reduces CRF in other cancer survivors, notably those with prostate cancer (Battaglini, 2011;Cramp & Daniel, 2008;Fong et al, 2012;Keogh & MacLeod, 2012;Monga et al, 2007).…”

Section: Physical Healthmentioning

confidence: 99%

“…Nevertheless, walking has been recognised as an achievable form of activity for most cancer survivors regardless of fitness levels or income (which may affect the resources a person has access to). Walking interventions have met with some success and have been shown to improve fitness, and reduce body fat and fatigue (Dimeo et al, 1997a;Matthews et al, 2007;Mock et al, 2005).…”

Section: Type Of Activitymentioning

confidence: 99%

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Physical Activity and Cancer

Bk¹,

Ih²,

Rohde³

2013

Encyclopedia of Behavioral Medicine

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It is widely accepted that physical activity is important for physical functioning and well-being, and as such the promotion of active lifestyles is becoming increasingly significant in public health policy both in the UK and worldwide. Sedentary lifestyles have been associated with increased risk of obesity and preventable disease including diabetes, coronary heart disease and some cancers. With regards cancer specifically, this chapter will provide a brief overview on current opinions on the link between physical activity and cancer prevention.The published evidence focuses both on primary and secondary prevention. More recent evidence has investigated the use of physical activity in secondary prevention for those who have been diagnosed with cancer and proposed a link between physical activity, morbidity and mortality in those with cancer. The evidence-base for secondary prevention is more limited. Nevertheless, studies to date have indicated that physical activity can improve both physical functioning and psychological outcomes in cancer survivors, and significantly improve quality of life.The exact nature of those interventions which confer the most positive effects is less well-established, and there is a current lack of consensus on the most appropriate type, intensity and duration of activity for people with cancer. It has not yet been wellestablished as to which stage of the treatment programme physical activity should be encouraged (during or following treatment) or the most appropriate length of time during which structured physical activity interventions should be delivered to achieve beneficial results.These factors will be discussed in this chapter, and barriers to engaging in physical activity for those with a diagnosis of cancer will be considered. The chapter will conclude with a summary of key findings and the potential for further research.

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Exercise manages fatigue during breast cancer treatment: A randomized controlled trial

Cited by 325 publications

References 61 publications

Impact of two different exercise programs on persistent cancer-related fatigue and physical fitness

Impact of two different exercise programs on persistent cancer-related fatigue and physical fitness

Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue.

Physical Activity and Cancer

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