Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence

McClernon, F. Joseph; Conklin, Cynthia A.; Kozink, Rachel V.; Adcock, R. Alison; Sweitzer, Maggie M.; Addicott, Merideth A.; Chou, Ying-hui; Chen, Nan‐kuei; Hallyburton, Matthew; Devito, Anthony M.

doi:10.1038/npp.2015.214

Cited by 42 publications

(43 citation statements)

References 44 publications

(68 reference statements)

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“…This also suggests that AI recruitment was likely optimized in the present study since the cocaine-paired context included tactile and olfactory, in addition to visual and auditory, stimuli. In further support of this possibility, drug-associated multi-modal contextual stimuli in particular elicit insula activation and an associated increase in subsequent smoking behavior in cigarette smokers (McClernon et al 2016). …”

Section: Discussionmentioning

confidence: 94%

“…Similarly, AI lesions in rats potentiate cocaine-seeking behavior after forced abstinence (Pelloux et al 2013). Thus, we speculate that tonic AI hypoactivity may contribute to heightened CS-induced AI activation in cocaine users (Kühn and Gallinat 2011) and increased drug context-induced AI activation and smoking behavior in cigarette smokers (McClernon et al 2016). Consistent with this, transient AI inactivation reliably inhibits CS- and drug context-induced drug-seeking behavior (present study; Cosme et al 2015; Pusharaj et al 2015a), and it can reduce impulsive behavior (Pushparaj et al 2015b; Ishii et al 2012, but see Onge and Floresco 2010) in rats.…”

Section: Discussionmentioning

confidence: 99%

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Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats

et al. 2017

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Rationale Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective. Objectives The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine-memory reconsolidation. Methods Rats were trained to lever press for cocaine infusions in a distinctive context, followed by extinction training in a different context. Rats in Experiment 1 received bilateral microinfusions of vehicle or a GABA agonist cocktail (baclofen and muscimol, BM) into the AI or the overlying somatosensory cortex (SSJ, anatomical control region) immediately before a test of drug-seeking behavior (i.e. non-reinforced lever presses) in the previously cocaine-paired context. The effects of these manipulations on locomotor activity were also assessed in a novel context. Rats in Experiment 2 received vehicle or BM into the AI after a 15-min re-exposure to the cocaine-paired context, intended to reactivate context-response-cocaine memories and initiate their reconsolidation. The effects of these manipulations on drug context-induced cocaine-seeking behavior were assessed 72 h later. Results BM-induced pharmacological inactivation of the AI, but not the SSJ, attenuated drug context-induced reinstatement of cocaine-seeking behavior without altering locomotor activity. Conversely, AI inactivation after memory reactivation failed to impair subsequent drug-seeking behavior and thus cocaine-memory reconsolidation. Conclusions These findings suggest that the AI is a critical element of the neural circuitry that mediates contextual control over cocaine-seeking behavior.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats

et al. 2017

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“…Following a screening/training visit, participants completed two separate cue exposure sessions approximately one week apart following ≥ 6 hrs smoking abstinence (confirmed by a 40% reduction in breath carbon monoxide (CO) level from the value obtained at either the screening or training visits) (Conklin et al 2010, McClernon et al 2016). The two sessions differed only on the environmental cues presented (smoking or nonsmoking; order randomly assigned and counterbalanced).…”

Section: Methodsmentioning

confidence: 99%

“…The two sessions differed only on the environmental cues presented (smoking or nonsmoking; order randomly assigned and counterbalanced). One session involved exposure to validated images (Conklin 2006, Conklin et al 2008, McClernon et al 2016) of standard smoking environment cues (e.g. car, bus stop, restaurant, and bars); the other exposure to standard nonsmoking environment cues (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…Drug dependent individuals experience craving following exposure to cues associated with past or current drug taking (Carter & Tiffany 1999, Conklin 2006, Drummond et al 1995, McClernon et al 2016). Despite recognition of environments as influential determinants of drug use and relapse in animal models (Fuchs et al 2008, Marchant et al 2015), only limited research has specifically evaluated the effects of drug-environments on drug self-administration in humans.…”

Section: Introductionmentioning

confidence: 99%

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Smoking environment cues reduce ability to resist smoking as measured by a delay to smoking task

Stevenson

Oliver

Hallyburton

et al. 2017

Addictive Behaviors

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Introduction Environments associated with smoking may promote lapse and relapse in smokers attempting to quit. Here we examined the effects of exposure to visual smoking environment cues on smoking urge and the ability to resist smoking, as measured with a delay-to-smoking task in which monetary contingencies are provided for resisting smoking. Methods Adult daily smokers (n=22) completed two experimental sessions, each following 6 hr smoking abstinence. Sessions differed only in the type of cue participants were exposed to (smoking environments vs. nonsmoking environments). Participants completed subjective ratings of smoking urge, withdrawal and other reactions (i.e. craving, affect). Behavioral outcomes on the delay-to-smoking task included latency to first cigarette, number of cigarettes smoked and average number of puffs per cigarette. Results Across cue exposure sessions, 64% of participants initiated smoking (no effect of condition was observed). However, exposure to smoking environments as compared to the nonsmoking environments resulted in greater craving, faster initiation of smoking, and more smoked cigarettes. Greater craving was associated with a shorter time to initiate smoking, but this effect did not differ across sessions. In contrast, withdrawal was more strongly associated with number of cigarettes smoked during smoking environment sessions. Conclusion Together, these results suggest smoking environments increase smoking urge and promote smoking behavior. Further research is necessary to examine the specific and interactive effects of smoking-related environments on real-world smoking lapse and relapse.

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Identifying Smoking Environments From Images of Daily Life With Deep Learning

et al. 2019

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Hippocampal and Insular Response to Smoking-Related Environments: Neuroimaging Evidence for Drug-Context Effects in Nicotine Dependence

Cited by 42 publications

References 44 publications

Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats

Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats

Smoking environment cues reduce ability to resist smoking as measured by a delay to smoking task

Identifying Smoking Environments From Images of Daily Life With Deep Learning

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