Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorder

Bas-Hoogendam, Janna Marie; Steenbergen, Henk van; Blackford, Jennifer Urbano; Tissier, Renaud; Wee, Nic J.A. van der; Westenberg, P. Michiel

doi:10.1002/da.22962

Cited by 10 publications

(11 citation statements)

References 75 publications

(140 reference statements)

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“…Second, we investigated responses to neutral faces. Data revealed that impaired neural habituation in the hippocampus met the two endophenotype criteria of interest 145 ; in addition, amygdala engagement in response to conditioned faces with a social-evaluative meaning qualified as a neurobiological candidate endophenotype of social anxiety 146,147 . Although future studies are required to examine the stability of these candidate endophenotypes over time (endophenotype criterion 2) and to discover genetic variants underlying the abovementioned candidate endophenotypes, these promising findings offer a starting point for follow-up studies on the genetic susceptibility to SAD.…”

Section: Endophenotype Research On Social Anxiety Disordermentioning

confidence: 98%

Imaging the socially-anxious brain: recent advances and future prospects

Bas-Hoogendam

Westenberg

2020

F1000Res

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Social anxiety disorder (SAD) is serious psychiatric condition with a genetic background. Insight into the neurobiological alterations underlying the disorder is essential to develop effective interventions that could relieve SAD-related suffering. In this expert review, we consider recent neuroimaging work on SAD. First, we focus on new results from magnetic resonance imaging studies dedicated to outlining biomarkers of SAD, including encouraging findings with respect to structural and functional brain alterations associated with the disorder. Furthermore, we highlight innovative studies in the field of neuroprediction and studies that established the effects of treatment on brain characteristics. Next, we describe novel work aimed to delineate endophenotypes of SAD, providing insight into the genetic susceptibility to develop the disorder. Finally, we outline outstanding questions and point out directions for future research.

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Section: Endophenotype Research On Social Anxiety Disordermentioning

confidence: 98%

Imaging the socially-anxious brain: recent advances and future prospects

Bas-Hoogendam

Westenberg

2020

F1000Res

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“…The Leiden Family Lab study on Social Anxiety Disorder (LFLSAD) is to our knowledge the first comprehensive two-generation family neuroimaging study on SAD and has been designed specifically to examine the heritability and first part of the co-segregation criteria of candidate endophenotypes of SAD ( Bas-Hoogendam et al, 2018a ). Previous results of this study suggest that several characteristics of brain structure and function, like cortical and subcortical GM characteristics, increased and prolonged amygdala activation, and increased brain activity whilst processing unintentional social norm violations, could be endophenotypes of SAD ( Bas-Hoogendam et al, 2018b , Bas-Hoogendam et al, 2019b , Bas-Hoogendam et al, 2019c , Bas-Hoogendam et al, 2020b , Bas‐Hoogendam et al, 2019a ). However, it still remains to be elucidated whether characteristics of WM microstructure could be candidate endophenotypes of SAD.…”

Section: Introductionmentioning

confidence: 65%

“…Participants with (sub)clinical SAD reported significantly higher levels of social anxiety (self-reported social anxiety symptoms (z-SA) and FNE), depressive symptoms and trait anxiety compared to their non-SAD relatives but did not differ with respect to gender-distribution, generation, age or IQ. For a more elaborate description of this sample, including diagnostic information and details on quality checking and data availability, we refer to the Supplemental section and previous publications on the LFLSAD in general ( Bas-Hoogendam et al, 2018a ) and the MRI sample in particular ( Bas-Hoogendam et al, 2018b , Bas-Hoogendam et al, 2019b , Bas-Hoogendam et al, 2020b , Bas‐Hoogendam et al, 2019a ).…”

Section: Resultsmentioning

confidence: 99%

“…Second, we conducted conventional TOI analyses using average individual values of WM parameters over the whole tract to allow comparison with previous literature (“average TOI analyses”) and to ensure continuity with previous analyses performed on data from the LFLSAD ( Bas-Hoogendam et al, 2018b ). That is, following methods previously described ( Bas-Hoogendam et al, 2018b , Bas-Hoogendam et al, 2019b , Bas-Hoogendam et al, 2020b , Bas‐Hoogendam et al, 2019a ), associations between individual average values of WM parameters (FA, MD, RD and AD over the whole tract) per tract and clinical symptoms of SAD (z-SA and FNE) were examined by performing multiple regression analyses using linear mixed models in R ( R Core Team, 2019 ). Average values of FA, AD, MD and RD were extracted for each individual unilaterally per tract.…”

Section: Methodsmentioning

confidence: 99%

“…Next, general heritability (h 2 ) of the WM microstructure characteristics was estimated, using methods previously used in analyses of the LFLSAD sample to ensure consistency ( Bas-Hoogendam et al, 2018b , Bas-Hoogendam et al, 2019b , Bas-Hoogendam et al, 2019c , Bas-Hoogendam et al, 2020b , Bas‐Hoogendam et al, 2019a ). This method estimates heritability by jointly modelling SAD status and the individual average values of FA, AD, MD, and RD within all TOIs in a multivariate-mixed probit model, by which the familial relationship and ascertainment of the families (based on SAD in the proband and (sub)clinical SAD in the proband’s SA-child) were taken into account ( Tissier et al, 2017 ).…”

Section: Methodsmentioning

confidence: 99%

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