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While the advent of Industry 4.0 is emblematic of national strategy for industrial revitalization, the proliferation of technology has drastically changed the landscape of many major sectors of global industries. Industry 4.0 encompasses multi-dimensional conceptsincluding computerization, digitization, and intelligentization-of business operations based on cyber-physical-systems (CPS) and the Internet-of-Things (IoTs). The vision of Industry 4.0 will bring about improvements in industrial processes, ranging from engineering, material usage, supply chains, and product lifecycle management, to the horizontal value chain. This research project adopts a descriptive analysis with descriptive statistics under the innovation policy framework proposed by Rothwell and Zegveld. This report also informs a comparative policy analysis across China and Taiwan. From the perspectives of industry coalition and competition, this cross-strait comparison lends itself to being a policy-making reference. Results reveal that China, in terms of policy-making, concentrates on 'political' and 'legal/regulatory' aspects of environmental policy, as well as the theme of 'public service' of the demand-side policy. Taiwan also emphasizes the 'environmental-side' policy like China, whereas Taiwan focuses more on 'education/training' of the supply-side policy.

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The antitumor effects of curcumin, a natural biologically active compound extracted from rhizomes of Curcuma longa, have been studied in many cancer cell types including human hepatocellular carcinoma (HCC). Here, we investigated the effects of Ca2+ on curcumin-induced apoptosis in human HCC J5 cells. The abrogation of mitochondrial membrane potential (ΔΨm), the increase of reactive oxygen species (ROS) production, and calcium release were demonstrated with flow cytometry as early as 15 minutes after curcumin treatment. In addition, an increase level of cytochrome c in the cytoplasm which led to DNA fragmentation was observed. To verify the role of Ca2+ in curcumin-induced apoptosis, 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA), an intracellular calcium chelator, was applied. Cell viability was increased, but ΔΨm, ROS production, activation of caspase 3, and cell death were decreased in J5 cells pretreated with BAPTA for 2 h followed by the treatment of 25 μM curcumin. These results suggest that the curcumin-induced apoptosis in human HCC J5 cells is via mitochondria-dependent pathway and is closely related to the level of intracellular accumulation of calcium.