Mapping White Matter Integrity and Neurobehavioral Correlates in Children with Fetal Alcohol Spectrum Disorders

Sowell, Elizabeth R.; Johnson, Arianne; Kan, Eric; Lu, Lisa H.; Horn, John D. Van; Toga, Arthur W.; O’Connor, Mary J.; Bookheimer, Susan Y.

doi:10.1523/jneurosci.5067-07.2008

Cited by 154 publications

(206 citation statements)

References 46 publications

(53 reference statements)

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“…The observed significant correlations in the total sample were, with the exception of a negative correlation between DR in a cluster in the Fmin and IQ in the control group, nonsignificant when the sample was split into controls and exposed children, suggesting that between-group differences, rather than individual differences within the group, drive these relationships. Sowell et al, 10 on the other hand, reported that FA of the CC splenium correlated with visuomotor integration only in an FASD group and not in controls. Both measures and the nature of the exposure differed across these studies, so they cannot be directly compared.…”

Section: Discussionmentioning

confidence: 98%

“…5,10 It has also been reported that children born to mothers with opiate and polysubstance abuse have smaller neuroanatomic volumes, including WM volume.…”

mentioning

confidence: 99%

“…Three DTI studies of WM characteristics in FASD have been conducted, and all reported effects in the posterior CC. 10,16,17 No DTI studies have been reported on effects of prenatal exposure to drugs of abuse other than alcohol.…”

mentioning

confidence: 99%

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White Matter Characteristics and Cognition in Prenatally Opiate- and Polysubstance-Exposed Children: A Diffusion Tensor Imaging Study

Walhovd

Westlye²,

Moe³

et al. 2010

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 98%

“…5,10 It has also been reported that children born to mothers with opiate and polysubstance abuse have smaller neuroanatomic volumes, including WM volume.…”

mentioning

confidence: 99%

See 1 more Smart Citation

White Matter Characteristics and Cognition in Prenatally Opiate- and Polysubstance-Exposed Children: A Diffusion Tensor Imaging Study

Walhovd

Westlye²,

Moe³

et al. 2010

AJNR Am J Neuroradiol

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“…Several studies have reported increased cortical thickness in diffuse regions across the frontal, temporal, and parietal lobes [50][51][52] while another study reported cortical thinning [53]. Longitudinally, children with prenatal alcohol exposure show less developmentally appropriate cortical thinning across time compared to controls [54].…”

Section: Maternal and Environmental Variablesmentioning

confidence: 99%

“…Effects of prenatal alcohol exposure are linked to reduced white matter structural integrity in the cerebellum [83] and abnormalities in axial diffusivity [84] as early as infancy. In addition, subtle changes in FA have been associated with deficits in cognitive function including processing speed, math ability, executive function, and eye-blink conditioning [50,81,[85][86][87][88][89][90][91][92] A recent study was also able to demonstrate that structural white matter changes are linked to disturbances in functional connectivity while at rest [83].…”

Section: Integrity Of White Matter Tractsmentioning

confidence: 99%

Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function

Willford¹,

Smith²,

Kuhn³

et al. 2016

Recent Advances in Drug Addiction Research and Clinical Applications

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Neuroimaging tools have provided novel methods for understanding the impact of prenatal drug exposure on brain structure and function and its relation to development and behavior. Information gained from neuroimaging studies allows for the investigation of how prenatal drug exposure alters the typical developmental trajectory. The current prevalence and characteristics of prenatal drug exposure and its implications for vulnerable periods of brain development are reviewed. Structural and functional neuroimaging methods are introduced with examples of how study results from prenatal alcohol, cocaine, marijuana, and tobacco exposure further our understanding of the neurodevelopment impact of prenatal drug exposure. Prenatal drug neuroimaging studies have advanced our understanding of mechanisms and functional deficits associated with prenatal drug exposure. Studies have identified brain circuits associated with the default mode network, inhibitory control, and working memory that show differences in function as a result of prenatal drug exposure. The information gained from studies of prenatal drug exposure on brain structure and function can be used to make connections between animal models and human studies of prenatal drug exposure, identify biomarkers of documented effects of prenatal drug exposure on behavior, and inform prevention and intervention programs for young children.

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Evaluation of Brain Alterations and Behavior in Children With Low Levels of Prenatal Alcohol Exposure

Long

Lebel

2022

JAMA Netw Open

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IMPORTANCEHigh levels of prenatal alcohol exposure (PAE) are associated with widespread behavioral and cognitive problems as well as structural alterations of the brain. However, it remains unclear whether low levels of PAE affect brain structure and function, and prior studies generally have not had well-matched control populations (eg, for sociodemographic variables). OBJECTIVE To compare structural brain alterations and behavioral changes in children with lower levels of PAE with those of well-matched controls with no PAE. DESIGN, SETTING, AND PARTICIPANTS In this cross-sectional study, participants were selected from the Adolescent Brain Cognitive Development study. Children with PAE were compared with controls matched for age, sex, family income, maternal educational level, and caregiver status.Neither group had prenatal exposure to other adverse substances (eg, tobacco, cannabis, illicit

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Mapping White Matter Integrity and Neurobehavioral Correlates in Children with Fetal Alcohol Spectrum Disorders

Cited by 154 publications

References 46 publications

White Matter Characteristics and Cognition in Prenatally Opiate- and Polysubstance-Exposed Children: A Diffusion Tensor Imaging Study

White Matter Characteristics and Cognition in Prenatally Opiate- and Polysubstance-Exposed Children: A Diffusion Tensor Imaging Study

Review of Current Neuroimaging Studies of the Effects of Prenatal Drug Exposure: Brain Structure and Function

Evaluation of Brain Alterations and Behavior in Children With Low Levels of Prenatal Alcohol Exposure

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