This study examines the psychometric properties of the Chinese version of Connor and Davidson's Resilience Scale (CD-RISC; 2003), an American instrument originating from a posttraumatic stress disorder research program. Confirmatory factor analysis of the Chinese data failed to verify the original 5-factor structure of CD-RISC obtained in the USA, while exploratory factor analysis resulted in a 3-factor structure of resilience (labeled respectively as Tenacity, Strength, and Optimism). The reliability coefficient of the Chinese version of CD-RISC was 0.91. The validity of CD-RISC was also satisfying in terms of the actual data matching the expected correlation between resilience measure and the variables of selfesteem, life satisfaction, and personality trait factors of NEO-FFI. It is concluded that the construct of resilience and its measurement from the West can be helpful and applicable in understanding Chinese adaptive behaviors, however, the understanding of the construct may also need some modification according to Chinese culture.

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Acute allograft rejection remains common after liver transplantation despite modern immunosuppressive agents. In addition, the long‐term side effects of these regimens, including opportunistic infections, are challenging. This study evaluated the safety and clinical feasibility of umbilical cord‐derived mesenchymal stem cell (UC‐MSC) therapy in liver transplant patients with acute graft rejection. Twenty‐seven liver allograft recipients with acute rejection were randomly assigned into the UC‐MSC infusion group or the control group. Thirteen patients received one infusion of UC‐MSCs (1 × 106/kg body weight); one patient received multiple UC‐MSC infusions; 13 patients were used as controls. All enrolled patients received conventional immunosuppressive agents with follow‐up for 12 weeks after UC‐MSC infusions. No side effects occurred in treated patients. Four weeks after UC‐MSC infusions, alanine aminotransferase levels had decreased markedly and remained lower throughout the 12‐week follow‐up period. Importantly, allograft histology was improved after administration of UC‐MSCs. The percentage of regulatory T cells (Tregs) and the Treg/T helper 17 (Th17) cell ratio were significantly increased 4 weeks after infusions; in contrast, the percentage of Th17 cells showed a decreasing trend. In controls, the percentages of Tregs and Th17 cells and the Treg/Th17 ratio were statistically unchanged from the baseline measurements. Transforming growth factor beta 1 and prostaglandin E2 were increased significantly after UC‐MSC infusions; by contrast, there were no significant changes in controls. Our data suggest that UC‐MSC infusion for acute graft rejection following liver transplantation is feasible and may mediate a therapeutic immunosuppressive effect. Stem Cells Translational Medicine 2017;6:2053–2061

The Chinese version of the CD-RISC2 was demonstrated to be a reliable and valid measure in assessing resilience among the general population in Hong Kong.

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