“…The failure to find group differences in the amygdala replicates prior work using a similarly crafted large, trans-diagnostic sample of GAD, SAD, and MDD participants during exposure to negative stimuli but outside the context of reappraisal . In addition, although numerous prior studies report overactive amygdala in response to varied negative stimuli (e.g., scenes, faces, and words), there are also number of studies that fail to find such effects in those with GAD and SAD (Blair et al, 2008;Burklund, Torre, Lieberman, Taylor, & Craske, 2017;Davies et al, 2017;Etkin, Prater, Hoeft, Menon, & Schatzberg, 2010;Mochcovitch, da Rocha Freire, Garcia, & Nardi, 2014;Nakao et al, 2011;Palm, Elliott, McKie, Deakin, & Anderson, 2011;Strawn et al, 2012;Whalen et al, 2008) or MDD (Almeida, Versace, Hassel, Kupfer, & Phillips, 2010;Beauregard et al, 2006;Davidson, Irwin, Anderle, & Kalin, 2003;Grimm et al, 2008;Irwin et al, 2004;Lawrence et al, 2004;Townsend et al, 2010). Lack of amygdala differentiation between patients and controls is also consistent with prior studies that did not find amygdala differences between HCs and those with GAD or HCs and those with MDD (Erk et al, 2010) during reappraisal specifically.…”