“…In addition to increased DNA damage, aneuploid cells experiencing replication stress (including those harboring DNA damage) are also subject to several other fates, such as cell cycle delays, DNA condensation defect, inappropriate mitotic entry, senescence, and even immunological recognition and destruction (Andriani et al, 2016; Blank et al, 2015; Burrell et al, 2013; Lamm et al, 2016; Meena et al, 2015; Santaguida et al, 2017; Soto et al, 2017). Cell cycle delays associated with replication stress may be a cause of the perturbation in cell cycle/proliferative dynamics observed for aneuploid cells in the past (Segal and McCoy, 1974; Stingele et al, 2012; Williams et al, 2008).…”