Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case–control study

Zhou, Zhaowei; Cui, Lingling; Han, Lin; Wang, Can; Song, Zhijian; Shen, Jiawei; Li, Zhiqiang; Chen, Jianhua; Wen, Zujia; Wang, Xiaomin; Shi, Yongyong; Li, Changgui

doi:10.1186/s12881-015-0208-8

Cited by 18 publications

(28 citation statements)

References 50 publications

(78 reference statements)

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“…This finding could explain the moderate LD ( r 2 = 0.868) between these two SNPs (rs1165196 and rs1183201) in CEU and strong LD (0.967) within CHB. Zhou et al [42] have successfully replicated similar findings in CHB males case–control study by showing that SNP rs1183201 was significantly associated with gout and SUA and in consistency with Kolz et al findings [17]. …”

Section: Discussionsupporting

confidence: 67%

“…A larger and appropriately powered study will be needed to ascertain the effect of these select SNPs on SUA levels and the presence of gout. Although some investigators have found an association with SUA and gout with other genes ( GCKR and LRRC16A ) [17,42,48], these genes were not evaluated in our population. Further investigations of direct associations with these genes and key other SNPs are worthy of direct study in this unique population.…”

Section: Limitationsmentioning

confidence: 99%

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Assessment of Genetic Polymorphisms Associated with Hyperuricemia or Gout in the Hmong

et al. 2016

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Aim Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two- to fivefold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese (CHB). Methods In total, 235 Hmong were genotyped for eight SNPs representing five candidate genes (SLC22A12, SLC2A9, ABCG2, SLC17A1 and PDZK1). Results The frequency of seven out of eight risk alleles in the Hmong was significantly different than CEU; six higher and one with lower prevalence. The frequency of three out of eight risk alleles in the Hmong was significantly different than CHB; two higher and one with lower prevalence. Conclusion Hyperuricemia risk alleles are more prevalent in the Hmong than CEU and HB.

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Section: Discussionsupporting

confidence: 67%

Section: Limitationsmentioning

confidence: 99%

Assessment of Genetic Polymorphisms Associated with Hyperuricemia or Gout in the Hmong

et al. 2016

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“…A study of a Spanish cohort showed that T allele of URAT1 rs11231825 (H142H) was associated with gout, in particular with patients who presented a reduced uric acid excretion [ 37 ]. In addition, there are some other URAT1 SNPs examined, but achieved conflicting results from different study populations, such as rs475688 [ 38 , 39 ], rs505802 [ 40 , 41 ] and rs2285340 [ 2 ].…”

Section: Membrane Transporters - Solute Carrier Familymentioning

confidence: 99%

“…Multiple genetic studies on GLUT9 gene have been conducted in gout. Rs734553 was associated with gout in German [ 41 ] and Han Chinese male [ 40 ] populations. Some of the reported gout-associated polymorphisms appeared inconsistent in different study populations.…”

Section: Membrane Transporters - Solute Carrier Familymentioning

confidence: 99%

Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout

2018

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Gout is a common form of inflammatory arthritis caused by hyperuricemia and the deposition of Monosodium Urate (MSU) crystals. It is also considered as a complex disorder in which multiple genetic factors have been identified in association with its susceptibility and/or clinical outcomes. Major genes that were associated with gout include URAT1, GLUT9, OAT4, NPT1 (SLC17A1), NPT4 (SLC17A3), NPT5 (SLC17A4), MCT9, ABCG2, ABCC4, KCNQ1, PDZK1, NIPAL1, IL1β, IL-8, IL-12B, IL-23R, TNFA, MCP-1/CCL2, NLRP3, PPARGC1B, TLR4, CD14, CARD8, P2X7R, EGF, A1CF, HNF4G and TRIM46, LRP2, GKRP, ADRB3, ADH1B, ALDH2, COMT, MAOA, PRKG2, WDR1, ALPK1, CARMIL (LRRC16A), RFX3, BCAS3, CNIH-2, FAM35A and MYL2-CUX2. The proteins encoded by these genes mainly function in urate transport, inflammation, innate immunity and metabolism. Understanding the functions of gout-associated genes will provide important insights into future studies to explore the pathogenesis of gout, as well as to develop targeted therapies for gout.

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“…Unfortunately the original version of this article [ 1 ] contained a mistake. It came to the authors’ attention that the corresponding authors of the article were not listed correctly, an error which arose during production.…”

Section: Erratummentioning

confidence: 99%

Erratum to: Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case–control study

et al. 2015

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Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case–control study

Cited by 18 publications

References 50 publications

Assessment of Genetic Polymorphisms Associated with Hyperuricemia or Gout in the Hmong

Assessment of Genetic Polymorphisms Associated with Hyperuricemia or Gout in the Hmong

Multiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout

Erratum to: Polymorphisms in GCKR, SLC17A1 and SLC22A12 were associated with phenotype gout in Han Chinese males: a case–control study

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