Social vision: Sustained perceptual enhancement of affective facial cues in social anxiety

McTeague, Lisa M.; Shumen, Joshua R.; Wieser, Matthias J.; Lang, Peter; Keil, Andreas

doi:10.1016/j.neuroimage.2010.08.080

Cited by 69 publications

(64 citation statements)

References 117 publications

(174 reference statements)

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“…In contrast with the lack of overt limbic hyper-response, it is relevant to note that the largest between-group difference was the increase in visual cortex activation in SAD. This finding is in concordance with previous studies postulating an important role of the visual cortex in emotional arousal at the perception level (Sabatinelli et al 2007(Sabatinelli et al , 2012McTeague et al 2011). In our assessment, symptom provocation was not associated with increased psychophysiological arousal, but instead SAD patients showed reduced heart rate responses.…”

Section: Discussionsupporting

confidence: 93%

Neural response to the observable self in social anxiety disorder

et al. 2012

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Background. Distorted images of the observable self are considered crucial in the development and maintenance of social anxiety. We generated an experimental situation in which participants viewed themselves from an observer's perspective when exposed to scrutiny and evaluation by others.Method. Twenty patients with social anxiety disorder (SAD) and 20 control subjects were assessed using functional magnetic resonance imaging (fMRI) during the public exposure of pre-recorded videos in which they were each shown performing a verbal task. The examiners acted as the audience in the experiment and rated performance. Whole-brain functional maps were computed using Statistical Parametric Mapping.Results. Robust activation was observed in regions related to self-face recognition, emotional response and general arousal in both study groups. Patients showed significantly greater activation only in the primary visual cortex. By contrast, they showed significant deactivation or smaller activation in dorsal frontoparietal and anterior cingulate cortices relevant to the cognitive control of negative emotion. Task-related anxiety ratings revealed a pattern of negative correlation with activation in this frontoparietal/cingulate network. Importantly, the relationship between social anxiety scores and neural response showed an inverted-U function with positive correlations in the lower score range and negative correlations in the higher range.Conclusions. Our findings suggest that exposure to scrutiny and evaluation in SAD may be associated with changes in cortical systems mediating the cognitive components of anxiety. Disorder severity seems to be relevant in shaping the neural response pattern, which is distinctively characterized by a reduced cortical response in the most severe cases.

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Section: Discussionsupporting

confidence: 93%

Neural response to the observable self in social anxiety disorder

et al. 2012

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“…Thus, the hyperactivation pattern within this region in SAD may reflect rapid detection of potential threatening stimuli at a perceptual level. Our findings are in accordance with previous reports in SAD using other paradigms (Herrmann et al, 2008;Pujol et al, 2013) and with proposals of the involvement of visual cortex in emotional arousal (Sabatinelli, Lang, Keil, & Bradley, 2007;McTeague, Shumen, Wieser, Lang, & Keil, 2011) and fit the pattern of early hypervigilance to facial expressions observed in SAD .…”

Section: Distinct Neural Activation In Sad and Wssupporting

confidence: 93%

Common and distinct neural correlates of facial emotion processing in social anxiety disorder and Williams syndrome: A systematic review and voxel-based meta-analysis of functional resonance imaging studies

Binelli¹,

Subirà²,

Batalla³

et al. 2014

Neuropsychologia

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“…Preferential and sustained cortical processing of fear-relevant cues in the absence of avoidance has been demonstrated in several studies assessing attentional capture by phobia-relevant stimuli (McTeague et al, 2011, Wieser et al, 2011, Wieser et al, 2012), whereas patterns of hypervigilance-avoidance have been less consistent, and most robust in eye-tracking studies (Pflugshaupt et al, 2005; Wieser et al, 2009). To the extent that ocular control is a complex mechanism which involves widespread cortical communication along with coordinated activity in several cortical and sub-cortical structures (Sommer and Wurtz, 2008), it is conceivable that a dynamic sequence of hypervigilance and avoidance is specific to eye movements.…”

Section: Discussionmentioning

confidence: 99%