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Prior research has shown that mothers with Interpersonal violence-related posttraumatic stress disorder (IPV-PTSD) report greater difficulty in parenting their toddlers. Relative to their frequent early exposure to violence and maltreatment, these mothers display dysregulation of their hypothalamic pituitary adrenal axis (HPA-axis), characterized by hypocortisolism. Considering methylation of the promoter region of the glucocorticoid receptor gene NR3C1 as a marker for HPA-axis functioning, with less methylation likely being associated with less circulating cortisol, the present study tested the hypothesis that the degree of methylation of this gene would be negatively correlated with maternal IPV-PTSD severity and parenting stress, and positively correlated with medial prefrontal cortical (mPFC) activity in response to video-stimuli of stressful versus non-stressful mother–child interactions. Following a mental health assessment, 45 mothers and their children (ages 12–42 months) participated in a behavioral protocol involving free-play and laboratory stressors such as mother–child separation. Maternal DNA was extracted from saliva. Interactive behavior was rated on the CARE-Index. During subsequent fMRI scanning, mothers were shown films of free-play and separation drawn from this protocol. Maternal PTSD severity and parenting stress were negatively correlated with the mean percentage of methylation of NR3C1. Maternal mPFC activity in response to video-stimuli of mother–child separation versus play correlated positively to NR3C1 methylation, and negatively to maternal IPV-PTSD and parenting stress. Among interactive behavior variables, child cooperativeness in play was positively correlated with NR3C1 methylation. Thus, the present study is the first published report to our knowledge, suggesting convergence of behavioral, epigenetic, and neuroimaging data that form a psychobiological signature of parenting-risk in the context of early life stress and PTSD.

In the context of a memory task, participants were presented with pictures displaying biological and cultural threat stimuli or neutral stimuli (stimulus relevance manipulation) with superimposed symbols signaling monetary gains or losses (goal conduciveness manipulation). Results for heart rate and facial electromyogram show differential efferent effects of the respective appraisal outcomes and provide first evidence for sequential processing, as postulated by Scherer's component process model of emotion. Specifically, as predicted, muscle activity over the brow and cheek regions marking the process of relevance appraisal occurred significantly earlier than facial muscle activity markers of goal conduciveness appraisal. Heart rate, in contrast, was influenced by the stimulus relevance manipulation only. #

Phobic individuals display an attention bias to phobia-related information and biased expectancies regarding the likelihood of being faced with such stimuli. Notably, although attention and expectancy biases are core features in phobia and anxiety disorders, these biases have mostly been investigated separately and their causal impact has not been examined. We hypothesized that these biases might be causally related. Spider phobic and low spider fearful control participants performed a visual search task in which they specified whether the deviant animal in a search array was a spider or a bird. Shorter reaction times (RTs) for spiders than for birds in this task reflect an attention bias toward spiders. Participants' expectancies regarding the likelihood of these animals being the deviant in the search array were manipulated by presenting verbal cues. Phobics were characterized by a pronounced and persistent attention bias toward spiders; controls displayed slower RTs for birds than for spiders only when spider cues had been presented. More important, we found RTs for spider detections to be virtually unaffected by the expectancy cues in both groups, whereas RTs for bird detections showed a clear influence of the cues. Our results speak to the possibility that evolution has formed attentional systems that are specific to the detection of phylogenetically salient stimuli such as threatening animals; these systems may not be as penetrable to variations in (experimentally induced) expectancies as those systems that are used for the detection of non-threatening stimuli. In sum, our findings highlight the relation between expectancies and attention engagement in general. However, expectancies may play a greater role in attention engagement in safe environments than in threatening environments.

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Both optimism bias and reward-related attention bias have crucial implications for well-being and mental health. Yet, the extent to which the two biases interact remains unclear because, to date, they have mostly been discussed in isolation. Examining interactions between the two biases can lead to new directions in neurocognitive research by revealing their underlying cognitive and neurophysiological mechanisms. In the present article, we suggest that optimism bias and reward-related attention bias mutually enforce each other and recruit a common underlying neural network. Key components of this network include specific activations in the anterior and posterior cingulate cortex with connections to the amygdala. We further postulate that biased memory processes influence the interplay of optimism and reward-related attention bias. Studying such causal relations between cognitive biases reveals important information not only about normal functioning and adaptive neural pathways in maintaining mental health, but also about the development and maintenance of psychological diseases, thereby contributing to the effectiveness of treatment.

Social psychophysiology is characterized by the use of noninvasive procedures to study the relationships between actual or perceived physiological events and the verbal or behavioral effects of human interactions. The field represents the intersection of social psychology and psychophysiology. Social psychology, the older of the two spawning disciplines, is directed toward understanding the reportable and behavioral effects of human presence and interactions, whereas psychophysiology employs noninvasive procedures to study the interrelationships between physiological events and a person's reportable or overt behavior.

People can be overly optimistic not only about their own future but also for the people with whom they identify. Furthermore, interpersonal perception generally forms along two universal dimensions, i.e. warmth and competence. In this study, we created four fictional characters that would map onto each quadrant of the two-dimensional space of warmth and competence, i.e. one in-group member (high on both warmth and competence) and three out-group members (high warmth, low competence; high competence, low warmth; low on both warmth and competence). We then asked respondents to assess the likelihood of each character experiencing a series of identical desirable and undesirable events in order to uncover potential optimistic biases. Our study had two goals. First, we wanted to balance the target desirable and undesirable events on four key characteristics, i.e. event frequency, controllability, emotional intensity and personal experience with the event. Second, we wanted to investigate whether stereotypes of warmth and competence could influence the respondents’ likelihood estimates for each character. We show that respondents manifested a strong desirability bias, expecting more desirable than undesirable events for the in-group member and the reverse pattern for the extreme out-group member. More important, we show that, within desirable and undesirable events, respondents anchored their judgments for the in-group member on their personal experience with the target events, further revealing an egocentric bias, but turned to stereotypical knowledge in the form of warmth and competence to judge out-group members. Implications for both social perception and optimism research are discussed.