“…This is largely because PA28γ was initially discovered during research studies into the serum of patients suffering from systemic lupus erythematosus (SLE). From its discovery, PA28γ has been implicated in many physiologic processes, such as cell proliferation, apoptosis [ 86 , 87 , 88 ], lipid metabolism [ 89 ], DNA repair [ 90 , 91 ], fertility [ 92 ], nuclear and chromatin organization [ 93 ], and a plethora of diseases including: cancers (breast [ 94 , 95 ], thyroid [ 96 ], lung, skin, colorectal [ 97 , 98 , 99 ], and oral [ 100 ]), neurodegeneration [ 101 , 102 , 103 ], cardiac hypertrophy [ 104 ], Hepatitis C infection [ 89 , 105 ], and SARS-CoV-2 [ 106 ].…”