No abstract

Unorthodox luminogenic polymers without aromatic luminogens have attracted great interest in recent years; however, the low fluorescence efficiency is still a big drawback. In this paper, we synthesized a fluorescent hyperbranched polysiloxane with both carbonyl and vinyl groups (P1). Surprisingly, it exhibited nontraditional intrinsic luminescence with the highest quantum yield up to 43.9% among the reported silica-containing hyperbranched fluorescent polymers to date. Reference oligomers P2 and P3, theoretical calculations, and transmission electron microscopy were employed to explore the fluorescence mechanism. The high fluorescence quantum yield is ascribed to the synergism of vinyl and carbonyl groups as well as the Si−O grouppromoted through-space conjugation. Thus, the supramolecular hyperbranched polysiloxane was assembled by conjugation to increase the oscillator strength and decrease the band gap. Moreover, the solvent effect and pH dependency properties of P1 and its application as an Fe 3+ probe were also studied.

Hyperbranched polysiloxane (HBPSi) is attracting increasing attention due to its intrinsic fluorescence and good biocompatibility. However, it is very challenging to explore its biological applications because of the low fluorescence intensity and quantum yield. Herein, we introduced rigid β-cyclodextrin to the end of flexible polysiloxane chain to synthesize a novel fluorescent polymer (HBPSi-CD) and explore its biological applications. Results showed that the fluorescence intensity and quantum yield of HBPSi-CD, compared with HBPSi, were significantly enhanced. Theoretical calculations and transmission electron microscopy demonstrated that the synergy effect of intra/intermolecular hydrogen bonds and hydrophobic effect promoted the formation of large supramolecular self-assemblies and space electron delocalization systems, leading to intense fluorescence. Notably, the biocompatible HBPSi-CD not only lighted up mouse fibroblast cells, but also possessed high ibuprofen loading capacity (160 mg g–1) and superior pH-responsive drug release performance. This work promoted the development of biological applications of HBPSi.

The study indicates the suitability of [(123)I]MIH for in vivo visualization of myocardial infarcts.

Translational oncology aims to translate laboratory research into new anticancer therapies. Contrary to conventional surgery, chemotherapy, and radiotherapy, targeted anticancer therapy (TAT) refers to systemic administration of drugs with particular mechanisms that specifically act on well-defined targets or biologic pathways that, when activated or inactivated, may cause regression or destruction of the malignant process, meanwhile with minimized adverse effects on healthy tissues. In this article, we intend to first give a brief review on various known TAT approaches that are deemed promising for clinical applications in the current trend of personalized medicine, and then we will introduce our newly developed approach namely small molecular sequential dual targeting theragnostic strategy as a generalized class of TAT for the management of most solid malignancies, which, after optimization, is expected to help improve overall cancer treatability and curability.

The presented work shows an impressive multicolour luminescence hyperbranched polysiloxane attributed to the multiring through-space conjugation named “multiring induced multicolor emission” (MIE), as well as its application in data encryption.

A novel kind of water‐soluble fluorescent hyperbranched poly(amino ester) (PAE) is prepared through a one‐pot polycondensation reaction of citric acid (CA) and N‐methyldiethanolamine (NMDEA). The PAE exhibits enhanced and red‐shift fluorescence with increasing solution concentration, showing distinct aggregation‐induced emission character. Interestingly, the resulting PAE exhibits tunable photoluminescence from blue, cyan, and green to red irradiated by altering the excitation wavelengths. Such unique emission of non‐conjugated PAE is attributed to the clustering of ester and tertiary amine groups derived from PAE self‐assembly aggregates. Moreover, the fluorescence of PAE is very sensitive to Fe3+ ions. The facile preparation and unique optical features make PAE potentially useful in numerous applications such as multicolor cellular imaging, Fe3+ ions probe, and light‐emitting diodes.

a b s t r a c tDespite the widespread use of various imaging modalities in clinical and experimental oncology without or with combined application of commercially available nonspecific contrast agents (CAs), development of tissue-or organ-or disease-specific CAs has been a continuing effort for pursuing ever-improved sensitivity, specificity, and applicability. This is particularly true with magnetic resonance imaging (MRI) due to its intrinsic superb spatial/temporal/contrast resolutions and adequate detectability for tiny amount of substances. In this context, research using small animal tumor models has played an indispensible role in preclinical exploration of tissue specific CAs. Emphasizing more on methodological and practical aspects, this article aims to share our cumulated experiences on how to create tumor models for evaluation and development of new tissue specific MRI CAs and how to apply such models in imaging-based research studies. With the results that are repeatedly confirmed by later clinical applications in cancer patients, some of our early preclinical studies have contributed to the designs of subsequent clinical trials on the new CAs, some studies have predicted new utilities of these CAs; and other studies have led to the discoveries of new tissue-or disease-specific CAs with novel diagnostic or even therapeutic potentials. Among commonly adopted tumor models, the chemically induced and surgically implanted nodules in the liver prove very useful to simulate primary and metastatic intrahepatic tumors, respectively in clinical patients. The methods to create tumor models have eased procedures and yielded high success rates. The specific properties of the new CAs could be outshined by intraindividual comparison to the commercial CAs as nonspecific controls. Meticulous imaging-microangiography-histology matching techniques guaranteed colocalization of the lesion on in vivo MRI and postmortem tissue specimen, hence correct imaging interpretation and longstanding conclusions. As exemplified in the real study cases, the present experimental set-up proves applicable in small animals for imaging-based oncological investigations, and may provide a platform for the currently booming molecular imaging in a multimodality environment.